Founded in 1702, the church was re-erected in 1734 to replace the original. However, its current edifice was built in 1822 following the second church's destruction.
In 1735, it received a charter from King George II.
During the American Revolution, Hempstead was a hotbed of British sympathizers or Tories, as they were known. The British attempted to occupy Hempstead after the Battle of Long Island and used St. George's as a headquarters as well as a place to worship. Local folklore has it that the rooster weather vane atop the steeple has sixteen bullet marks placed there by Hessian mercenaries who used it for target practice.
Both the church and its rectory are listed on the National Register of Historic Places.